Let Trajectories Speak Out the Traffic Bottlenecks

Time to let the patient speak.

"Listen to the complaint of the patient, however tiresome or irrelevant that may seem. He will eventually tell you what is the matter with him.... It is usually better in terms ofboth care and time to allow the flow to come to a natural halt from exhaustion of either the speaker or the material." The first half of this advice (from an experienced advocate and judge in medicolegal cases and a he...

Editorial: Daring to Speak Out

When we commented on the Brussels bombings in Issue 3, we did not imagine that further shocking violence would be in the forefront of our minds only a few months later. Two horrific events in recent weeks have brought tragedy to the lives of individuals and families and forced into public consciousness issues of principle which lie at their heart. The mass shootings in the early hours of Sunday...

Silent pericentromeric repeats speak out.

Pericentromeres are essential structural components of the chromosome that function to ensure proper sister chromatid segregation during cell division. These chromosomal domains are composed of major satellite DNA repeats whose constitutively heterochromatic structure facilitates kinetochore formation (1). Characteristically demarcated by the silencing histone mark trimethyl-histone-3lysine-9, ...

Let the data speak: a response to Terracciano (2014).

Characterising acute coronary syndrome-associated depression: Let the data speak.

Depression in the context of acute coronary syndrome (ACS) is understood to confer increased morbidity and mortality risk. The pathophysiological mechanisms underlying this association remain poorly understood, although several candidates including inflammation, cardiac autonomic dysregulation, and behavioural factors are viewed as of key importance. No single bio-behavioural explanatory model ...